Department of Surgery banner with links to Home,, and the School of Medicine Click here for the Department of Pediatrics Home Page Click here for the UC Irvine Home Page Click here for the School of Medicine Home Page


Surgeons at UC Irvine have been responsible for many new technologies and therapies to improve healthcare. In fact, UC Irvine is ranked among the top 50 U.S. medical schools for research and primary care, according to U.S. News & World Report rankings.

UC Irvine's Department of Surgery conducts basic research and industry-supported clinical and basic research studies. Committed to remaining at the leading edge of these and many other research efforts, including the exponentially expanding field of cell transplantation, tissue preservation, cell processing and expansion.

We welcome your interest in our research activities and are committed to helping medical students, surgical trainees and young investigators establish mentoring relationships with our faculty. If you are interested in the research activities occurring within our department, please contact Dr. Jeffry Nahmias or Dr. Maheswari Senthil for more infromation.

Basic Science Research Studies

  • Development of Bio-Artificial Pancreas for Diabetes
  • Efficacy of Radiation and Sunitinib on Cancer and Stroma in Pancreas Cancer
  • Enhancing Islet Cell Survival by Inhibiting Apoptosis
  • The evaluation of enteral protease inhibitor for shock 
  • Hypertonic Resuscitation Following Traumatic Injury
  • Imaging Pancreatic Islets In-Vivo
  • The Inflammatory Response to Brain Death

Current Clinical Research Studies

  • Comparing the safety and efficacy of concentration-controlled Everolimus (Certican,) with low dose Tacolimus (Prograf)  to Cellcept ® (mycophenolate mofetil) with standard dose Prograf in de novo renal transplant recipients
  • The Effect Of Acadesine On Clinically Significant Adverse Cardiovascular and Cerebrovascular Events In High-Risk Subjects Undergoing Coronary Artery Bypass Graft (CABG) Surgery Using Cardiopulmonary Bypass
  • The Efficacy, Immunogenicity, and Safety of a Single Dose of Merck 0657nI Staphylococcus aureus Vaccine (V710) in Adult Patients Scheduled for Cardiothoracic Surgery
  • Evaluation of the use of endoscopic stent in management of esophageal leaks after esophagectomy
  • Compression Anastomosis Ring (CAR 27/Colon Ring) Post Marketing Evaluation Study
  • Ischemic Conditioning (Delay Phenomenon) in Colorectal Cancer Surgery
  • Laparoscopic gastric bypass vs. Laparoscopic gastric banding for the treatment of morbid obesity
  • Observational Long-Term Follow-Up of Living Donors (Kidneys) in an Unique Ethnically Diverse Patient Population
  • Participation in the American Association for the Surgery of Trauma (AAST) Multi-Center Studies
  • Participation with the American College of surgeons Bariatric Surgery Center Network studies
  • Participation in the Research Outcomes Consortium (ROC) Hypertonic Saline for TBI Study
  • Prospective SICU DVT Prevention Study with an Emphasis on Low Molecular Weight Heparin Dosing
  • The Relationship Between Parenteral Nutrition, Hyperglycemia and Nosocomial Infections in the SICU
  • Rabbit Anti-thymocyte Globulin Versus Basiliximab in Deceased Donor Renal Transplants Using a Risk-Adjusted Immunosuppressive Clinical Protocol
  • Randomized trial of intragastric balloon for the treatment of obesity
  • Retrospective study of impact of bariatric surgery on improvement or resolution of comorbidities
  • Retrospective Trauma and Burn Registry Studies
  • The role of gastric ischemic conditioning in esophagectomy
  • Timing of Rectal Cancer Response to Chemoradiation. Multi-center Study(COH/NCI)